"All eyes are on the meeting between Greece and Europe," Ramiro Loureiro, a Lisbon-based market analyst at Banco Comercial Portugues's Millennium unit, told Bloomberg Business. "Investors are proving to be cautious regarding the outcome."
The euro dropped 0.4 per cent to US$1.1344, after earlier in the day rising as much as 0.3 per cent.
The Stoxx Europe 600 Index ended the day with a 0.1 per cent decline from the previous close.
The FTSE 100 Index fell 0.2 per cent, as did France's CAC 40 Index, while Germany's DAX slid 0.4 per cent. Greece's Athens Stock Exchange General Index dropped 3.8 per cent.
"The market consensus is for them to do a deal by the end of this week," Susanne Galler, a strategist with Jefferies in London, told Reuters. "But we think that if there's no deal today and the clock starts ticking then the euro will look increasingly vulnerable."
US financial markets were closed for the President's Day public holiday on Monday.
Oil moved higher amid concern about escalating violence in Libya. Egypt's air force bombed Islamic State targets in Libya after the extremist group released a video purporting to show the beheading of 21 Egyptian Christians.
Benchmark Brent futures added 28 cents to US$61.80 a barrel after earlier in the session touching US$62.57 a barrel, the highest in two months.
"A lot of the oversupply is very tenuous, and that's why we are prone to rebound," John Kilduff, a partner at Again Capital, a New York-based hedge fund that focuses on energy, told Bloomberg. "We are on a tripwire really."
Copper ended little changed and volumes continue to thin ahead of the start, later this week, of the China Lunar New Year.
Gold, in contrast, extended its advance in part due to concerns about the talks between Greece and its EU partners as well as a weaker US dollar.