A 19-year-old man sustained life-threatening injuries when he was shot in a shopping centre car park in Columbia, Missouri on Thursday night, however local authorities said it appeared to be an accident and not related to Black Friday shopping.
Police said two men who knew each other were sitting in a vehicle when one fired a shot as he placed his gun in his holster, KSHB Kansas City reported.
Elsewhere, some went to extreme lengths to bag a bargain by attempting to pose as store staff to get inside first.
A Twitter user wrote it was a "good thing [he] kept [his] vest from Walmart when [he] quit" and that he would be "skipping everybody" by wearing it to pose as a staffer.
Americans are predicted to spend $US20 billion ($29b) during the Thanksgiving weekend, according to the National Retail Federation.
A survey found 115 million Americans planned to hit the shops on Black Friday alone.