The university said work would begin on demolishing many of the old brewery facilities as soon as it took possession of the site in June.
Its first projects will be the total refurbishment of some existing buildings and the construction of a new civil structures hall.
"This work will be a prelude to the extensive refurbishment and new build of the Faculty of Engineering facilities on the City Campus at a cost in the region of $200m," it said.
Development of the site would have "major implications" for Newmarket in in the future.
"The number of people living, or commuting into, Newmarket will at least double over time.
"This influx will affect transport decisions, residential housing, infrastructure, amenities - and, of course, the business direction of Newmarket."
AMP tried to buy the site last decade for about $160 million but ditched those plans when the global financial crisis hit, leaving Lion with the land, after the brewery and food business shifted its hub to South Auckland.