This added a combined estimated annual turnover of about $US2.1 billion, she said.
"This acquisition spree has continued into 2022 with the recent purchases of Australian-based Jalna Dairy Foods and German-based Bayerische Milchindustrie's (BMI) fresh dairy division."
Rising to third was France's Danone with a turnover of $US20.9 billion, swapping places with US-based Dairy Farmers of America on $US19.3 billion.
China's Yili was fifth with $US18.2 billion, up from $US13.8 billion.
Higgins said last year saw Fonterra complete the sale of its two wholly-owned China farming hubs.
"The company's disposal of DPA Brazil and Soprole, along with potential changes in the Australian-based business, are still pending," she said.
"Despite the sales of its Chinese hubs, greater China remains an important market for Fonterra - particularly for food service sales - as do other countries in the broader Asia-Pacific region."
Fonterra's annual results for this financial year will be announced next month.
The recovery in food service channels last year after the initial Covid pandemic and continued strong retail sales with firm global dairy demand assisted the top dairy companies.
Higgins said dairy product prices rallying to elevated levels from lower-than-anticipated milk production growth in the main exporting regions and exceptionally strong Chinese import demand also acted in its favour.
Another trend is that dairy companies are moving from just acknowledging their climate and sustainability ambitions for 2050, towards setting targets.