Emergency services are attending a crash between a car and a motorbike on State Highway 25, Thames Coast Rd.
A police spokeswoman said the crash, between Pohue Creek Rd and Otuturu Cr, was reported at 12.35pm.
One person is reported to have sustained moderate injuries, she said.
A St John spokesman said there was an ambulance, a rapid response vehicle, and a helicopter were sent to the scene.
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One person with serious injuries was taken to Waikato Hospital by helicopter, he said.