Five people have been injured after a single-vehicle crash at Tirohanga in the Taupō district.

A police spokesman said police received a 111 call about the crash on Tirohanga Rd between the intersections of Okama Rd and Tram Rd at 12.20pm today.

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The crash scene was about two or three kilometres from State Highway 1, the spokesman said.

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Two people suffered serious injuries and another had moderate injuries, he said.

The Serious Crash Unit was investigating. No further details were available.

According to a St John report, two seriously injured people were flown to the Waikato Hospital by a rescue helicopter.

Another patient with moderate injuries and two others with minor injuries were taken to the Rotorua Hospital by road ambulance.