He said it was the worst annual figure since 2009 when 384 people were killed.
"There are far too many families who are missing a loved one these holidays after road accidents this year. It's devastating to know that many of these deaths were preventable," he said.
"Although road deaths as a proportion of our population and in comparison to the number of cars on the road has halved in the past 20 years, we can do much better. We can work together to reduce the number of deaths."
Nash said the main contributing factors were speed, failure to wear a seatbelt, distraction such as using a cellphone and the impairment from drugs, alcohol or fatigue.
"Police remain out on the roads working hard to keep everyone safe. But they can't do it alone- we need to be responsible every time we get behind the wheel."
The official holiday period ran from December 24, 2018, to Thursday January 3, 2019.
The number of national deaths so far stands at eight.