The second half began with an immediate try to Chiefs tighthead prop Ben Afeaki, after lock Brodie Retallick charged down an aimless clearing kick.
Blues-reject Gareth Anscombe converted brilliantly from the sideline chalk to give the Chiefs a 17-3 lead and all the early momentum
The Chiefs' brilliant attacking ability clicked into gear in the final 20 minutes when they scored four more tries - most starting deep in their own half.
Cane was clearly the standout player on the park and the time he spent in the All Blacks camp last year has clearly taken his game to a new level - particularly his tackling.
"I think I have improved and technically I feel pretty good at the moment," Cane said.
"I am going low and trying to work on keeping my feet going so I am not just taking their feet out but on the odd occasion driving them back as well.
"Making consecutive tackles is just work rate and getting back off the ground and back into the line because you are no good to anyone when you are on the deck."
Cane is pleased with the start to the campaign and can't wait to get stuck into the Stormers and Kings.
"We are all looking forward to getting to Cape Town.
"We don't get to go there all the time and the Stormers will be a heck of a challenge over there."
Chiefs v Cheetahs
Chiefs 45 (Liam Messam, Ben Afeaki, Asaeli Tikoirotuma, Gareth Anscombe, Rhys Marshall, Ben Tameifuna tries; Anscombe 6 cons, pen).
Cheetahs 3 (Johan Goosen pen)