He will be replaced at second-five by Anton Lienert-Brown and, with all due respect to the New Zealand Under-20s utility, Ma'a Nonu has gone from facing a serious rival for his All Blacks jersey to a man with only 79 minutes to his name this season.
Lowe, meanwhile, has succumbed to a shoulder ailment that has plagued the wing throughout the past fortnight, seeing Bryce Heem promoted from the bench and Marty McKenzie brought into the match day 23.
It's an especially cruel blow for Lowe, who was looking forward to testing himself against a pair of players he called "the two best wingers in the world". And Steve Hansen would have been a keen observer of Lowe's performance against Julian Savea and Cory Jane, given the 22-year-old has played his way into the All Blacks frame during a breakout campaign.
Instead, an under-powered Chiefs may wisely decide against meeting fire with fire, opting to avoid the strengths of a team ranked second in the competition for points and tries scored. That could see the visitors keep it tight, play a territory game and attempt to strangle the life out of their opposition, a fate made more likely by the forecast.
Wellington has been drenched all week and the skies show no sign of drying up ahead of kick-off with rain forecast from 6pm onwards. Speaking earlier in the week when poor weather looked inevitable, Chiefs coach Dave Rennie acknowledged a change in approach could be required for his side, and that was before he was forced to revamp his backline.
"I think both sides will probably kick a little bit more than they would have," he said. NZME.