St John Ambulance said a person sustained serious injuries and was taken by ambulance to Hawke's Bay Hospital.
A Hawke's Bay District Health Board spokeswoman said the man in his 20s remained on Friday afternoon in a serious but stable condition.
A police spokeswoman said Waitangi Rd was cleared and reopened to traffic about 5.17am.
It followed an earlier crash on Thursday night, where the driver of a car that crashed into a fence in Napier fled the scene.
Emergency services were called to the single-vehicle crash on Latham St, Napier South, about 10.07pm.
Fire and Emergency New Zealand said the driver was no longer at the scene when emergency services arrived.
Police also attended and said nobody was injured.
Police received a report of a car that crashed into a fence on Te Mata Peak Rd on Thursday. Photo / Warren BucklandPolice also received a report of a car that crashed into a fence on Te Mata Peak Rd about 8.13pm on Thursday.
Police said the driver fled the vehicle and the scene.
Inquiries are ongoing.