Isolation periods for Covid-19 cases and their household contacts will be reduced from 10 to seven days from midnight on Friday, March 11.
The Whanganui DHB said two people remained in hospital locally.
Current cases were in Whanganui, Rangitīkei, Ruapehu and South Taranaki.
The DHB's daily cases numbers now included those in South Taranaki, as its boundary extends up to the Pātea River.
A total of 42,000 RAT tests had been given out from the region's main vaccination centre Te Rito, the DHB said.
Te Rito moved from Victoria Ave to the former Ministry of Social Development premises in Wicksteed St on February 25.
The Whanganui DHB region is currently sitting at 90.7 per cent fully vaccinated against Covid-19, with 74.6 per cent of those eligible receiving a booster shot.