The Māori All Blacks are coached by Clayton McMillan with Moana Pasifika coached by former All Blacks captain Tana Umaga.
General manager of venues, tourism and major events Sean Murray said FMG Stadium Waikato was the perfect venue for the match.
"We're delighted to have this event come to Hamilton and value the commitment from New Zealand Rugby in bringing this match to our stadium. We also know that rugby fans will be passionate supporters of either side and it will be great to have that sort of excitement and energy in the venue again after what's been a challenging year," said Murray.
It will be a big weekend of international sport for Hamilton with the first cricket test between the Blackcaps and West Indies also taking place.
This test at Seddon Park from Thursday, December 3 to Monday, December 7 signals the start of the city's international summer cricket season.
The positive impact major sporting events have on Hamilton has been welcomed by mayor Paula Southgate.
"These games provide a really wonderful lift for the city. They bring out the crowds and create a real atmosphere.
"They also get people out spending locally and that's great for our hospitality sector, which has struggled with Covid-19. Hamilton does big sporting events really, really well so game on!"