Messam will start at No8, with the captain replacing the injured Maama Vaipulu, leaving Michael Fitzgerald to switch to blindside flanker and make room for Retallick.
Props Pauliasi Manu and Ben Tameifuna return to join Hika Elliot in the front row, replacing Jamie Mackintosh and Siate Tokolahi. Tokolahi moves to the reserves and is joined by Taranaki prop Mitchell Graham, who could make a Super Rugby debut.
One of only three unbeaten teams after two rounds of Super Rugby, the Chiefs know how significant games against the Crusaders have become.
"Our matches against the Crusaders have become very competitive and combative encounters," coach Dave Rennie said. "Everyone loves to play in these fixtures as they are the closest thing you can get to a test match, so it should set up a great spectacle for the fans."
Chiefs team to play Crusaders in Hamilton on Saturday night:
1. Pauliasi Manu
2. Hika Elliot
3. Ben Tameifuna
4. Matt Symons
5. Brodie Retallick
6. Michael Fitzgerald
7. Sam Cane
8. Liam Messam (c)
9. Augustine Pulu
10. Aaron Cruden
11. James Lowe
12. Sonny Bill Williams
13. Charlie Ngatai
14. Bryce Heem
15. Tom Marshall
Reserves
16. Quentin MacDonald
17. Siate Tokolahi
18. Mitchell Graham
19. Johan Bardoul
20. Sean Polwart
21. Brad Weber
22. Damian McKenzie
23. Seta Tamanivalu