A person is in critical condition this morning after a crash near the Matamata turnoff on State Highway 5.
A police media spokeswoman confirmed the road had reopened at 2.35pm.
She said the Serious Crash Unit attended the scene and inquiries were ongoing.
A St John spokeswoman said a helicopter had initially been called but was stood down.
She said one patient in a critical condition and two in a moderate condition were being transported by road to Waikato Hospital.
It was initially reported that three vehicles were involved.
The crash happened near the intersection of State Highway 5 and Whites Rd.
A witness at the scene said the crash happened about 10.30am.
The road was partially blocked and traffic control was in place. Police were diverting traffic, and motorists were being urged to avoid the area if possible.
Police, fire and ambulance services were all in attendance.