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police spokeswoman said a car left the road and went down a bank just past Oxford Rd around 11:30am.
Initial indications suggested serious injuries, she said.
The road was closed for some time but has since reopened.
A Fire and Emergency NZ spokesman said two appliances were called to the scene, one crew from Lake Rotomā and one from Kawerau.
A St John spokeswoman said three St John vehicles were sent to the scene.
Meanwhile, one person has been taken to Taupō Hospital in a serious condition after a crash on Poihipi Rd near Taupō this morning.
Another person was treated for minor injuries at the scene.
More to come.