The new pizza outlet, which will celebrate its official opening on November 11, is the brothers' first business.
The teenagers - Kaedyn is 19 and Liam is 18 - started working for Domino's in their hometown of Hastings when they were 12, before moving to the Napier outlet, where they both eventually attained roles of shift managers.
The new store has created 10 jobs for Rotorua.
Liam said the two brothers were thrilled to be able to pass their new skills and knowledge on.
"We are looking forward to helping others grow as we have.
"This is not only our first business, but our first time living away from home."
Kaedyn and Liam said the inclination of Rotorua pizza eaters to pick up their pizzas [rather than have them delivered] had made it easier to get to know the community.
"We sold more than 275 pizzas on our first day, so we had a good chance to meet a lot of our future regulars," said Kaedyn.
The pair will mark the opening of the new outlet by decorating the store with balloons, running in-store specials and having Domino's national mascot Pepperoni Pete on-site to greet customers.