The same cancer killed her mother at the age of 56.
So the odds are pretty high and, yes, Jolie can afford the best breast reconstruction surgery on the market - but that's not really the point.
She is a woman who is famous because of her talent, looks and glitz and glam lifestyle.
Her physical appearance has a lot to do with that and it must have been a big decision to make.
Despite what some people think, there is no guaranteed cure for cancer and such a decision had to be made to ensure more years with her six children.
Jolie has come a long way - from the Gothic-looking slightly attention-seeking actress of more than a decade ago to someone who cares about the world and is a good role model for other women.
So grin and bear the media frenzy for a bit longer if you can, for once we are standing around the water cooler talking about someone from Hollywood for the right reasons.