State Highway 2 between Opotiki and Gisborne is closed at the Waioeka Gorge following a slip.
The slip is around 36km from Opotiki.
The NZ Transport Agency says people are asked to avoid the area or find an alternative route if they can.
It says geotechnical engineers will assess the site on Thursday.
For more information on the closure visit www.nzta.govt.nz/traffic, call 0800 4 HIGHWAYS (0800 44 44 49) or by following the Transport Agency on Facebook or @nztawaibop on Twitter.