"This damage to the property, in addition to the clean-up required afterwards, is time-consuming, costly and stressful for our staff and volunteers."
However, it wasn't the only store to be targeted, with their Waipukurau shop having a similar experience on Monday.
CEO Janice Byford Jones said it was "hard to understand" why somebody would do this.
"I think most people respect the work that we do and it is not something that we are used to happening to us," she said.
The Cranford Hospice Stores are vital for the charity's fundraising and are a hive of activity.
Each year they must raise $2.8 million from the community in order to provide free, specialist, palliative care to dying people and support for their families in Hawke's Bay.
Byford Jones said she "guessed one of the motivations is that they need some sort of help and I would like to think that there are other agencies in the community that could help people if they do need this help rather than having to resort to stealing from other members of the community".