Volunteers at the Cancer Society's op-shop on Victoria Avenue are reducing the prices of items for a closing down sale this week.
The shop, which will close mid-September, has been popular with Whanganui bargain hunters since it opened in October 2014.
"The lease expired last December," said manager Jane Beamsley.
"The executive committee made the decision to close the shop and not seek another location."
Ms Beamsley said although there are other empty shops in town, the rents were not afforadable for the society.
"The society has a restored furniture shop in Maria Place and the decision has been made to focus on that."
Ms Beamsley said the op-shop had had a part-time manager working with a group of 12 "treasured" volunteers.
"The shop could not have functioned without them and we are forever grateful for their generous donation of time and dedication," she said.
As well as keeping the shop clean and tidy, the volunteers would often take items home to wash and repair.
Starting work as a volunteer herself, Ms Beamsley has worked in a number of different roles for the Cancer Society over the past seven years and became manager of the Whanganui branch earlier this month.
She faced a big challenge last week when the supplier was unable to provide the usual number of blooms for Daffodil Day on Friday.
"It could not be helped, the supplier did their best but there just weren't enough flowers in bloom - and you can't force nature."
Ms Beamsley said the society was grateful to all the people who had rallied to help the annual flagship event go ahead in the Whanganui region.
"To New World for donations of bunches of blooms, all the people who bought flowers in from their gardens, the schools and businesses who organised events and everyone who helped - thank you," she said.
The amount of money raised is not known yet as Ms Beamsley said there are still a number of contributions to be delivered and counted.