Another person pondered whether their deaths may be a seasonal occurrence. Others blamed poor water quality and climate change.
The mystery intensified, as according to the local who announced the discovery, cockles, tuatua, mussels, oysters and Karahue Snail were alive amongst the dead pipi.
Live pipi were also found in the water, locals say.
The ministry spokesperson said MPI and the local iwi had teamed up to determine the cause. As part of their investigation samples of the pipi would be collected.
They said in no circumstances should the shellfish be collected or eaten.
More information is expected to be known in the coming days.
The Advocate also contacted the Department of Conservation for further comment.