The New Zealand Transport Agency (NZTA) said delays were expected on SH1 at Brynderwyn for some time.
Traffic controls were put in place just after 3am, with the road fully closed for some time.
A spokesperson said an investigation was under way to determine the cause of the crash.
More FM Northland reported the crash was between a car and a logging truck, between the SH12 intersection at Brynderwyn and Atlas Quarries.
NZTA urged motorists to delay their journey if possible to allow extra time for a detour via Paparoa, which is suitable for heavy vehicles.
St John has been approached for comment.
Brodie Stone covers crime and emergency for the Northern Advocate. She has spent most of her life in Whangārei and is passionate about delving into issues that matter to Northlanders and beyond.