A female was transferred to Hawke's Bay Hospital in a critical condition via rescue helicopter.
A male, in his 60s, was also treated at Hawke's Bay Hospital, but was later discharged.
Hawke's Bay Today understands from a witness at the scene that the motorbike had two riders on it at the time of the collision with the truck, which was turning out of a side road.
The road reopened around 1.30pm, more than seven hours after the crash.
This morning several travellers who were at the cordon decided to wait until the road re-opened, rather than turning back. Emergency services handed out water bottles to keep those wanting to get through hydrated.
The majority of traffic coming from the Napier side was stopped at Eskdale and turned around, although officials did allow some traffic further down the road.
Police thanked the public for their patience.
