One of the earliest Red Cross shops was set up in Napier in 1915, and given the significance of the 100 years, and the initial association with WWI, a series of commemorative events are now planned.
A display of some early items along with old photos has been set up in the Napier Red Cross service centre.
"It is quite a history and we will be commemorating that," Red Cross East Coast community service manager Debbie Cullen said.
The centennial is being celebrated as the "Century of Care".
A Red Cross shop was also set up in Hastings with volunteers selling second-hand clothing as well as baked goods to raise money for the organisation to carry out its humanitarian work.
That volunteer spirit continues today with Red Cross shops still operating in both cities as well as Havelock North and Onekawa.
During the year street banners will be put up in Napier and Hastings commemorating the 100 years and on May 9 the film In Love and War will be shown at the MTG Hawke's Bay.
An honours and awards ceremony will be staged in Central Hawke's Bay next week to recognise the efforts of many long-standing volunteers.
In September a fashion show will take place at the War Memorial Conference Centre on Marine Parade, featuring old Red Cross uniforms.
There will also be a major combined volunteer function for about 300 people in December.-The Red Cross helps groups with first aid training and is currently offering aid to cyclone-torn Vanuatu.