Emergency services are responding to a rolled truck near Kereru, 42km west of Hastings.
The crash, involving a single truck and trailer, occurred on Kereru Rd about 8.30am on Monday, a police spokesperson said.
The road is "completely blocked", he said.
Two people who suffered moderate injures were taken to Hawke's Bay Hospital, one via a St John ambulance. The male driver in his 50s flown by the Lowe Corporation Rescue Helicopter.
Emergency services also responded to a truck crash on Weber Rd, near Waitahora, 23km southeast from Dannevirke, about 5.50am on Monday.