Synthetic cannabis was not the cause of violence, Ms Warren-Clark said, as that was just making an excuse for the behaviour. Continuing to use a substance that made a person violent was a choice.
"But what's happening is these men are awful to be around, horrible, violent and unpredictable.
"Most of the women who live with domestic violence learn ways to manage their partner's violence and keep him calm but when these guys are using that stuff, it's very similar to P and the come-down is awful."
A lot of women had been coming to the refuge for advice and support since the impending ban was announced.
Ms Warren-Clark said her clients had spoken of their partners' withdrawal symptoms lasting about two weeks, including diarrhoea, vomiting, sweats, grinding of the teeth and feeling anxious.
"They're the sorts of things we equate with coming off hard drugs. We've been noticing it has been slowly taking over the problems we've been having with methamphetamine. Certainly we still have meth use but on a day-to-day basis we hear of the partners using synthetics."
While some users may be stockpiling the drugs, Ms Warren-Clark believed many would not be able to afford to do so and a large proportion of the using population would be suffering withdrawals at the same time.
As a crisis centre, there was not much the refuge could do before trouble struck, but Ms Warren-Clark said whether at home or in the safe house, the women and their children would be looked after. "We will work as hard as possible to keep these people safe."