Researchers from St Petersburg State University in Russia sequenced the genome of seven cheetahs from Tanzania and Namibia, including a male called Chewbaaka.
The endangered species is currently found in the wild in eastern and southern Africa.
The study found a total of 18 cheetah genes showed damaging mutations. One in particular AKAP4, was found to suffer a large number of mutations that could harm sperm development.
This, the researchers say, could help to explain why cheetahs have such difficulty breeding.
The animals appear to have lost a considerable number of immune related genes.
They say the findings, which are published in the journal Genome Biology, could be used to help in future efforts to improve cheetah numbers.
- Daily Mail