Five people remain in hospital after a serious crash involving several vehicles in Lindis Pass yesterday afternoon.

A 36-year-old man from one vehicle, and a 35-year-old man and three women aged 27, 30, and 31 from a second vehicle, were all hospitalised with serious injuries, police said.

The cause of the crash, which took place at about 4.50pm on Lindis Pass, Central Otago, was being investigated, police said. No cause had yet been determined.