After two false starts, preschooler Chace Topperwien has finally begun a promising new drug trial his parents hope will help save their little boy's life.

Ryan and Keri Topperwien were "excited and relieved" when Chace, who has a rare and aggressive form of leukaemia, began a 72-hour infusion of the expensive drug in a hospital near London yesterday.

The Hamilton couple were expecting the worst because just days before Chace was so ill it looked like he might be sent back to New Zealand without even starting the phase one trial, aimed at inhibiting the growth of cancer cells.

The 3-year-old had already undergone a 24-hour infusion of the drug last week when doctors at the Royal Marsden Hospital in Surrey had to stop the treatment because Chace's intravenous lines blocked.


Mr Topperwien said his son fought back from rock bottom, sitting up in the middle of the night asking for "Weet-Bix" and showing doctors he was a battler. "It's exciting and relieving to be giving Chace what we came over here for," he said.

The couple whisked Chace to Britain last month in a final attempt to save his life after doctors in New Zealand told them his acute myeloid leukaemia had relapsed in January and there was nothing more they could do.

That was following a stem cell transplant in July last year after Chace was diagnosed with the cancer just days before his second birthday last March.

Now the aim is to keep Chace alive long enough for him to undergo a second transplant of bone marrow which can't be done within a year of the last one because it would be too toxic for the little boy's body.

Chace's bone marrow is more than 90 per cent leukaemic and doctors will give his body up to 42 days following the infusion to get that down to 25 per cent.

Mr Topperwien said it was a tall order but one that doctors would not compromise on if Chace was to remain in the four-month trial.

He said Chace's roller-coaster health was challenging for everyone.

"It can change so much in 12 hours. It can go from really good to really bad to really good to really bad all in a day."

The couple have been appealing to the public to help pay for the medical trial, which could cost up to $440,000, and for more Maori and Pacific Island bone marrow donors to help find a match for Chace when the time is right.

Fundraising efforts and donations, including two of $25,000 each from wealthy expatriate businessmen Eric Watson and Owen Glenn, have boosted the family's account to $125,000.

Mr Topperwien said a neighbour of his father's in Whakatane had generously given $5000.

Other donations, from strangers including New Zealanders in London, continued to pour in, for which they were very grateful.

"We want to thank everyone for the positive thoughts and prayers that are coming over to us, and the New Zealand community over here in London."

* Donations can be made to the Chace Topperwien. Fundraising account: 12 3217 0163111 00 at ASB.

* Find out how to donate bone marrow at

* For updates and fundraising details visit the Chace Topperwien Facebook page or a new website called, which has already raised $6000.