One person is critically injured and three others seriously, following a crash on State Highway 3 near Whanganui.
The crash occurred near the Whangaehu River bridge shortly before 5pm on Tuesday when a ute and van collided.
A police spokesperson said initial indications were one person has critical injuries while three others sustained serious injuries.
A helicopter was called to transport one person to hospital and the road was closed for around two hours while the Serious Crash Unit examined the scene.
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The road is now open.