Kick off your sightseeing at San Miguel Mission, reputed to be the oldest standing church building in the United States. Two Spanish priests, with the help of local Tlaxcalan Indians, built the humble mission, which was extended into a bigger building in 1610 - the remains can still be seen today.
Next door is the sumptuous Loretto Chapel, which positively glows in the sunlight, and was modelled on France's La Chapelle. Explore the interior of the chapel and its curious spiral staircase, which keeps visitors guessing.
The physics of the staircase's construction, which has no visible means of support, and the identity of its designer are the two great mysteries of Loretto Chapel.
Wine buffs should sample the rich reds of New Mexico at the local vineyards, just north of town. If you're visiting in winter, Ski Santa Fe, just half an hour from the town centre, has a base elevation of 3km.
Snowbunnies rave about this field, notably its steep bump runs, torrents of groomers and snow-filled channels. But you could quite happily plump for more sedentary pursuits such as shopping, noshing and lingering in the city's atmospheric lanes, which are packed with eye-catching boutiques and art galleries.
The most famous street of all is Canyon Rd, an extravagant 3km expanse of galleries, studios, shops and restaurants. Another requisite stop is the Plaza, dating back 400 years to the city's beginnings, where traders from as far away as Missouri drove their goods-laden wagons.
Today the Plaza is home to local Indians selling jewellery and pottery. The neighbouring Palace of the Governors is an enduring monument to Santa Fe's colonial heritage of Spanish and Mexican rule.
The city centre boasts some magnificent museums, but the Fine Arts Gallery is my favourite. The century-old building is a grand specimen of adobe architecture, featuring 20,000 artworks.