There were two people in each vehicle, with three initially deemed to be in a serious condition and one moderate.
Volunteers from Kaitaia Fire Brigade prepared a helicopter landing zone at Taipā Rugby Club.
SH10 remained closed for more than two hours while the injured were taken away and the scene cleared.
A spokesman for Hato Hone St John said two helicopters, two ambulances and one manager responded.
Two people were airlifted to Whangārei Hospital in a serious condition and two patients were transported to Kaitaia Hospital by ambulance in a moderate condition.
A police investigation into the cause of the crash is continuing.