Her success follows a gold-medal win at her international boxing debut, winning her 69kg weight division at the Arafura Games in Darwin, Australia.
Tauranga Boxing Club coach Chris Walker says Nicholson wants to back up her success with another gold medal this weekend but says it will be no easy task.
"She'll have to fight to win. She'll have to be her best," Walker says.
Nuku, Walker says, has nothing to lose this weekend and is feeling confident and hungry.
She also represented New Zealand at the Arafura Games, coming away with a bronze medal, and this weekend will likely come up against Commonwealth Games bronze medalist Troy Garton, who beat her by unanimous decision at last year's National Championships.
"She's the underdog and has nothing to lose," Walker says.
The three remaining Tauranga Boxing Club members will all make their Golden Gloves debut over the weekend. Promising light heavyweight boxer Henry Wilson, who hails from Te Puke, is boxing in a competitive novice division, while two Maketu youngsters, Te Kehu Kerr and Motekiai Hunt, will debut in the cadet divisions.
"[Wilson's] a tough character, he's a tough kid, he'll give it a good crack.
"Everybody's really been looking forward to it," Walker says.
Double Boxing New Zealand age-group champion Hannah Walker was to be chasing her fourth Golden Gloves title this weekend but Walker says he has had to pull her out of the event.
2019 Golden Gloves – Tauranga Boxing Club entries:
Female 69kg: Ariane Nicholson.
Female 60kg: Michelle Nuku.
Male Novice 81kg: Henry Wilson.
Cadet Novice: Te Kehu Kerr, Motekiai Huni.