The treatment did not deter the progression of the disease and the couple returned to New Zealand - and their new-born son - and settled into the Tauranga hospice.
Ms Nicholson came to Tauranga because her newborn son, Ryder, was transferred to Tauranga Hospital from Auckland where he was born.
Ms Nicholson's sister Ariane Adlington lives in Tauranga as does another close family friend who helped care for Ryder while his parents were in Melbourne.
Last week, New Zealand band Fat Freddy's Drop performed via Skype for Mrs Nicholson, who was a huge fan of the dub/reggae group.
A post on Facebook page Charlie's Angels, broke the devastating news.
"Charlie Richelle Loise Nicholson passed away peacefully late last night surrounded by her husband, family and friends," wrote a family spokeswoman.
"On behalf of Charlie, Shawn and our family we would like to thank everyone for their love, support and help through these past few months.
"Funeral arrangements for Gisborne are being made and once I have more information I will let everyone know. Thank you again from the bottom of our hearts to you all."