Gabriel Landeskog had a goal and two assists, while Jan Hejda and Nathan MacKinnon also scored for the Avalanche.
Dany Heatley scored for Minnesota, which did have some positive news as Zach Parise returned to the lineup much earlier than expected after a foot injury, but the Wild still lost a third straight.
Chicago's Ben Smith finally netted after a marathon shootout, giving the Blackhawks a 2-1 win over Dallas and a fifth-straight win.
Chicago's Patrick Sharp and Dallas' Rich Peverley had the only goals through the first 10 rounds of the tiebreaker. Each of them scored in regulation, too.
The 11-round shootout was the longest in the NHL for three years.
Stars defenseman Stephane Robidas broke his right leg when he slid hard into the boards in the second period.
Chicago has won six straight against the Stars and five in a row at Dallas.
Pittsburgh's Chris Kunitz scored twice as the Penguins beat Tampa Bay 3-0, notching an eight-straight win over the Lightning.
Marc-Andre Fleury stopped all 21 shots while Sidney Crosby had assists on all three goals, with Brandon Sutter also finding the net.
Tampa Bay had been bidding to tie a club record with an eighth consecutive home win.
Boston's Zdeno Chara and Patrice Bergeron scored third-period goals to lift the Bruins to a 3-2 win over the New York Rangers, opening a three-point lead over Tampa Bay atop the Atlantic Division.
Brad Marchand also scored for Boston, which has not lost in regulation time at home for ten games.
Rick Nash and Ryan McDonagh scored for the Rangers, who were playing their first game in Boston since losing to the Bruins in last year's playoffs.
Anaheim's Dustin Penner had two goals in the Ducks' 5-2 win over Calgary.
Saku Koivu had two assists in his long-awaited return to the lineup, while Sami Vatanen, Corey Perry and Andrew Cogliano also scored for the Ducks, who boast a franchise-record 10-0-1 home record.
It was Anahiem's 18th win in a row over the Flames at home, dating back ten seasons.
Washington's Mikhail Grabovski tied the score in the third period and had the go-ahead goal in a shootout to help the Capitals edge Montreal 3-2, halting a four-game skid.
Philadelphia's Scott Hartnell and Sean Couturier provided the offense while Steve Mason stopped all but one shot as the Flyers skated to a 2-1 victory over Winnipeg.
Detroit's Daniel Alfredsson had two goals and an assist, Darren Helm had two goals and Jimmy Howard made 29 saves as the Red Wings thumped the New York Islanders 5-0, getting their first regulation victory there in a decade.
New Jersey's Jaromir Jagr had a goal and two assists, and the Devils scored four times in the third period to beat Carolina 5-2.
Buffalo's Christian Ehrhoff scored 38 seconds into overtime to give the Sabres a 3-2 win over Toronto, ending a five-game losing streak.
Columbus' Ryan Johansen had a goal and an assist for his seventh multipoint game this season to lead the Blue Jackets to a 4-2 defeat of Edmonton.