Five people have been taken to Southland Hospital after a crash on Bluff Highway, near Invercargill, this afternoon.

Southern District Command Centre Senior Sergeant Craig Dinnissen said the crash happened at 2pm when a Honda Accord and SUV collided.

Three women and two children were taken to hospital by ambulance, with a woman in the SUV believed to have broken her collarbone, he said.

A St John spokesman said it sent three ambulances to the crash site.

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The three women -- one aged in her teens, one in her 20s and one in her 40s -- suffered moderate injuries, while two children had minor injuries, he said.

The road was closed after the crash but had reopened about 4pm.