Fifth-place Arsenal moved just two points behind Chelsea in the battle for a top-four place by beating Reading 4-1, ruining Nigel Adkins' first game in charge of a team that's now bottom of the standings.
It was Bale's 27th goal for club and country this season a tally that has made him a contender for the player of the year award and is keeping Spurs on course for a return to the Champions League.
"He's an amazing player," Tottenham manager Andre Villas-Boas said of Bale. "When he finds a small amount of space, he can produce something special."
Everton beat Stoke 1-0 courtesy of a wonderful solo goal by Kevin Mirallas to stay sixth, two points behind Arsenal, while West Ham and Wigan also won to ease their relegation fears.
City produced one of their best performances of the season to sweep aside Newcastle, with Carlos Tevez, David Silva, Vincent Kompany and Yaya Toure all scoring, but manager Roberto Mancini has given up hope of catching United.
"It's important to get second place and to win the FA Cup semifinal next week," said Mancini, indicating his priorities for the rest of the season.
United barely had to break sweat to see off disappointing Sunderland, who are just a point clear of relegation trouble and looking for a new manager after the announcement of O'Neill's departure that ended the Northern Irishman's 15-month tenure at the northeast club. However, United needed Bramble to deflect in Robin van Persie's shot to clinch victory at the Stadium of Light, the venue where Ferguson's team had the title ripped from its grasp on the final day of last season.
The leaders remained on course to break Chelsea's record from 2004-05 of 95 points from a single campaign and requires just 10 points from their last eight games to extend their record haul of championships.
"We're getting closer and it's one game less," United midfielder Michael Carrick said. "We have to keep going."
The battle for third and fourth is proving more eventful, with Chelsea the big losers this weekend.
Chelsea went the way of Man City and Liverpool, who also lost at St Mary's this season.AP