No one was trapped in the vehicle, and there was no spillage of cargo on to the road.
Fire crews assisted with the road closure.
Police said the crash initially blocked both lanes of the highway and a detour was in place until early Wednesday afternoon.
Waka Kotahi reported at 1.35pm on Wednesday the road had reopened after the vehicle was removed and the site cleared.
Finn Williams is a multimedia journalist for the Whanganui Chronicle. He joined the Chronicle in early 2022 and regularly covers stories about business, events and emergencies. He also enjoys writing opinion columns on whatever interests him.