St John are attending to seven patients, including people from the bus and the car, who are all in a moderate condition, a spokeswoman said.
Five people have been taken to Taumarunui Hospital, with a further two people transported to Taupo Hospital.
The Herald understands that dozens of people were on board the bus.
Fire and emergency services central shift manager Murray Dunbar said two trucks responded to the crash just after 3pm.
"We received a report that a bus had slid off the road into a ditch."
No people were trapped inside either vehicle, he said.
It is unclear what type of bus was involved in the crash.
More to come
