Fafetetai Siona and Matt Ashworth each scored two tries for Kaierau while teammates Kohit Coveney, Joe Edwards, Ethan Robinson and Sieko Kilisi all got one.
Shandon Scott successfully struck three conversions, while Josefa Rokotakaia also kicked one to finish a 31-point scoring second half for Kaierau.
The loss leaves Pirates second from the bottom of the table and still pointless in 2019.
At Memorial Park in Taihape it was another high-scoring thrashing as Byford's Readimix Taihape put 56 on the board to Round Motors Ratana's 0.
Tyler Rogers-Holden and Dylan Gallien had games to remember for Taihape, each scoring three tries while Dane Whale also came close to a hat-trick, scoring two.
Tremaine Gilbert and Ryan Karatau also dotted down for Taihape, while Whale also kicked two conversions and Jaye Flaws one.
The early rounds have been challenging for bottom placed Ratana who have scored only three points in two games with 147 scored against them.
In senior championship action Speirs Food Marton beat Black Bull Liqour Pirates 55-7, Kelso Hunterville overcame Marist Buffalo's 39-17, Waverley - Marist Celtic hammered Border 62-14, Kaiwhaiki – Utiku OB edged out Counties 24-12 and Bennett's Taihape took out Kaierau 34-23 for the Stihl Shop Wanganui Challenge Shield.