Adesanya then stuffed or scooted away from virtually every Wilkinson attempt at a double-leg takedown to begin the second round, as he began to measure his opponent with the long jab and then rapid combinations with knees and punches.
Physically spent, Wilkinson began to cover up and lay on the cage as Adesanya, barely even sweating, began to pound on him non-stop, using the punch to the ribs to set up knee strikes and then more heavy straight punches.
The referee was watching closely and as the bloodied Wilkinson began to slowly sink down the cage under the barrage, the official stepped in to wave the fight off at 3m 37s of Round 2.
Adesanya wasted no time in his post-fight interview to make it clear to the UFC's other fighters that he was here to stay.
"It's been a long time, definitely [to get here].
"It's been a few years and I had some other things to take care of, but I'm here now.
"All you middleweights...I see you creeping on my Instagram, but then I'm backstage and you act like you don't know me.
"Well, you know me now."
Adesanya praised Wilkinson, who he claimed took the fight after four others had turned it down.
He had felt at home in the octagon and scoffed at the suggestion of being under pressure in his hyped debut.
"The pressure makes diamonds – you know what it is.
"Middleweights, I'm the new dog in this yard, and I just pissed all over this cage."