Mr Griffiths said the goal of road safety agencies was for a repeat of Easter Weekend in 2012 and Queen's Birthday Weekend 2013, when there were no road deaths, along with fewer injuries.
"It would be outstanding if we were able to repeat that result this weekend - and beyond. That will mean fewer crosses marking our roadsides, fewer families grieving and fewer New Zealanders left with life-altering injuries.
"Since 1956 more than 560 people have been killed and 14,600 injured in crashes on our roads on Easter weekends," he said.
ACC is supporting the police speed enforcement effort, which includes an advertising campaign reminding drivers to slow down, said ACC chief executive Scott Pickering.
"Last year ACC received around 80 injury claims a day over Easter from road crashes, including everything from head injuries to smashed and bruised limbs," he said.
During the long weekend police will also be joining Australian Police in Operation Crossroads, to focus awareness on road safety issues.