Mrs Hardy said the project, which runs for six months, is funded by Whanganui and Partners, who contributed $10,000 to cover liability and admin fees.
The artists whose works are on display are Kate St Amand, Sandra Brumby, Val Donkervoort, and Paul Gibbs.
"It's a great opportunity for all of us," Ms St Amand said.
Mr Gibbs called it an "incredible journey".
Ms Donkervoort said they would take turns manning the shop, and Whanganui people could expect to come into the gallery and perhaps see one of the artists painting in the back.
Five per cent of the art sales are donated to Jigsaw Whanganui.
Mrs Hardy said they hoped to extend the project for longer than six months and were looking to set up many different art types in other stores, including polished driftwood sculptures, corrugated iron artworks, and other creative pieces.