One of Hamilton's main streets is closed following a crash.

A police car is blocking Te Rapa Rd after a man suffered a medical event and crashed the car he was driving.

A police spokeswoman said officers were called to a house on the street to investigate a domestic incident. Before they arrived at the address a man, who had been involved in the dispute, had run away.

While police were at the house another man, who was driving down Te Rapa Rd, crashed.

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The two incidents were unrelated, the spokeswoman said.

A reporter at the scene said police were taking photos near Target Furniture and a police car was parked beside the Streetwise coffee cart.