Two male motorcyclists are confirmed dead - and two young women are seriously injured - after a crash on the Lindis Pass this afternoon.

Both the injured women are aged 20.

One has been flown to Dunedin Hospital by helicopter and the other taken to the Cromwell Medical Centre by ambulance, an ambulance spokeswoman said.

Police said the crash on State Highway 8 involved two motorcycles and a car.

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Emergency services were called to the scene at Goodger Road, about 20 km north of Tarras, at 2.15pm.

State Highway 8 is closed and is not expected to be reopened before 7 pm.

Serious crash investigators are investigating the cause of the collision.

With no detour available, police have asked the public to be patient and respect the road closure.