A small study of 16 people with severe anorexia has found that implanting stimulation electrodes into the brains of patients could ease their anxiety and help them gain weight.
Researcher published in The Lancet Psychiatry journal on Friday said, in extreme cases of the eating disorder, the technique - known as deep brain stimulation (DBS) - swiftly helped many reduce symptoms of either anxiety or depression, and improved their quality of life.
A few months later, the improved psychological symptoms began to lead to changes in weight, the researchers said, with the average body mass index (BMI) of the group increasing to 17.3 - a rise of 3.5 points - over the course of the study.
Anorexia is a serious eating disorder that affects around 0.5 per cent of people worldwide, the majority of them teenage girls. Patients have persistent concerns about their weight, shape and size, and starve themselves to maintain a low weight.
Chronic anorexia can be fatal, and in many cases causes severe health problems including weak bones and muscles, sexual problems, infertility, heart problems and seizures.
DBS is already used to target brain circuits involved in Parkinson's disease and tremors - and been shown to be very effective in reducing symptoms.
In this trial, 16 women aged between 21 and 57 who had had anorexia for an average of 18 years and were severely underweight. They were chosen because all other treatments had not worked and their lives were at risk from the disorder.
Comparing brain scans from before and after the treatment, the researchers found there were changes in regions linked to anorexia, suggesting the DBS was able to directly affect the related brain circuits.
Professor Andres Lozano, who led the study, said that while the results showed some early promise, more research would be needed.