History is steeply against Australia, only four teams have ever won in Johannseburg batting last.
The record fourth innings run chase at The Wanderers ground is 294 set by Australia in 2006 and unless the tourists can roll South Africa quickly on day four, their struggling top order are facing a record pursuit on a fourth and fifth day pitch.
Debutant fast bowler Pat Cummins had put Australia in a strong position with two wickets in the first session of day three, but despite a few close calls, South Africa didn't crack again.
Cummins (2-46) was by far the standout, with his more experienced fast bowling partners Mitchell Johnson (0-77) and Peter Siddle (0-41) struggling for confidence and inspiration.
Before the day started to get away from Australia, 18-year-old Cummins announced himself as a Test star and the future leader of the attack with a brilliant performance in the opening session.
Under-pressure fast bowler Johnson drastically shortened his run-up, determined to try anything in a bid to return to form and stay in the team.
The desperation measure didn't work and Johnson remained wicketless.
Cummins and five-game rookie spinner Nathan Lyon (1-41) stepped up, but Johnson continues to see his Test future flash before his eyes.
Proteas openers Jacques Rudolph (24) and Graeme Smith (36) had comfortably progressed to 40 without loss before a Cummins bouncer caused Rudolph to miss-time his hook and pop one straight up for Brad Haddin to take with the gloves.
Smith and Amla got going for a while as well but persistent bowling from Lyon eventually cracked the South African skipper and Smith carelessly guided one to Phil Hughes at backward point to make the score 2-75.
Cummins was at his best in the 28th over when he worked out danger man Jacques Kallis (2) with a ball that did just enough and got an edge to Michael Clarke at second slip.
- AAP