Crotty looked comfortable at centre for the Crusaders last year in the wake of Robbie Fruean's heart problem, and he played well there when coming on for the All Blacks late last year.
Whether he can provide the penetration the Crusaders have been lacking so far remains to be seen, but with three clean breaks and eight defenders beaten, Crotty has been by far his team's most elusive player.
Israel Dagg has been re-instated to fullback after playing on the left wing.
Another feature of the team is the naming of Fijian international Nemani Nadolo on the reserves bench.
The 125kg wing scored two tries for the Crusaders development team at the weekend after recovering from a knee injury on his arrival from Japan.
Ben Funnell starts at hooker, with Corey Flynn unavailable due to a fractured eye socket.
The Rebels have begun their season with a big win at home over the Cheetahs and a 32-7 defeat to the Force in Perth.
However, the Crusaders have struggled against them in recent seasons.