Drivers are advised that Airport Rd remains closed and avoid the area completely as the vehicle recovery is underway.
The New Zealand Transport Agency said people will be unable to get to Hamilton Airport from the State Highway 1, Tamahere.
The agency advises people to use State Highway 3 to access the airport and allow extra time as there are roadworks at the Ohaupo intersection.
A Waikato Police District spokeswoman said: "The truck was fully loaded and ended up on top of the car. A very lucky escape as there were no serious injuries.
"The driver and the female solo driver of the car were taken to hospital.
"The vehicle recovery has been at the scene and the roads should be back to normal soon."