Formed in 1946, it operated with four divisions: Family Works - social services for children and their families, Cranford Hospice, Enliven Positive Aging Service and Real People - services for people with disabilities and neurological illnesses.
Presbyterian Support East Coast also won the Pan Pac Large Business Award.
CEO Sanja Majstorovic thanked all those involved in the awards, thanked clients for the privilege of working beside them and "our passionate staff".
The Westpac Excellence in Business Leadership Award went to Pan Pac managing director Doug Ducker.
Mr Ducker, celebrating 40 years with the company, said leadership was only as good as the people following.
He said Hawke's Bay had magnificent resources and people, but regional growth required ongoing co-operation and collaboration.
Chamber CEO Wayne Walford said judges were impressed with the quality of businesses that put themselves forward.
"This is a great way for businesses to identify opportunities for growth," he said.
"One of the benefits of entering the awards is that the finalists all receive feedback from the judges - a free business performance analysis for their business.
"Past entrants who have made the suggested changes from the judges' feedback have shown increased vitality and profitability in their business."
A Christmas tree was auctioned for Cranford, raising $800.
More than 300 celebrated the awards at a transformed Hawke's Bay Showgrounds Exhibition Hall with entertainment provided by the Hicksville Stompers and Lost 45s.